Gregory II Cyprius (Greek Γρηγόριος ο Κύπριος) (Lapithos, Cyprus 1241–1290) was patriarch of Constantinople between 1283-1289.

His name was originally George. His parents were middle class but of noble origin. He moved to Nicosia as a teenager seeking further education. Not satisfied by the level of education provided by local teachers in Greek, he became a student at a Latin school (available then as Cyprus was a crusader Kingdom). He had difficulty learning Latin and thus got only a superficial knowledge of grammar and Aristotle's Logic.

Still determined to get a decent education, he got on a ship to Ptolemais, Palestine, where he arrived after three days. From there he travelled to Anaea in Asia Minor and finally made it to Ephesos. He had heard a lot about the scholar Blemmydes but was disappointed by him and moved to Nicaea were he studied with

He became patriarch in 1283.The orthodox and the catholic churches had proclaimed their union in 1274 in the Second Council of Lyons, motivated more by the emperor's politics than by theological arguments. Gregory, contrary to his predecessor refused to accept the filioque clause added to the Nicene creed by the Roman Catholics. Gregory spoke of an eternal manifestation of the Spirit by the Son. Gregory's formula has been considered an Orthodox "answer" to the filioque, though it does not have the status of official Orthodox doctrine. Gregory's perception of Trinity was endorsed by the council of Blachernae in 1285.

He wrote collections of proverbs and his autobiography. He died in 1290.