The Holy Spirit Church (Slovak: Kostol svätého Ducha) or Hospital Church of the Holy Spirit (Slovak: Špitálsky kostol svätého Ducha) is the eldest building in Košice-Juh, Košice, Slovakia.

It is a baroque church erected between 1730 and 1733. The capacity of the interior is moderate - it is only for 200 people. The vault painting is highly interesting. It shows a view of Košice of the first third of the 18th century, when the town was surrounded by high town walls. The whole

The church is situated in the axis of former hospital buildings erected in the 13th century. The word hospital used to be a designation of a charity organization for the very old, the poor, orphans, the homeless, the sick. The hospital was situated outside the town walls and the church was a part of it from the beginning. Unfortunately, it was pulled down in the beginning of the 18th century.

At present, the House for pensioners is placed in the building. Kostol svätého Ducha